Restoration of the reduced CLSP activity alleviates memory impairment in Alzheimer disease

Calmodulin-like skin protein (CLSP), a secreted peptide, inhibits neuronal death in cell-based Alzheimer’s disease (AD) models and transgenic overexpression of the CLSP gene suppresses synaptic loss and memory impairment in AD model mice, APPswe/PS1dE9 double transgenic mice (APP/PS1 mice). Despite...

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Vydáno v:Transl Psychiatry
Hlavní autoři: Hashimoto, Yuichi, Kusakari, Shinya, Nawa, Mikiro, Okamoto, Koichi, Toyama, Yuka, Matsuoka, Masaaki
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7806720/
https://ncbi.nlm.nih.gov/pubmed/33441550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-020-01168-8
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