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Restoration of the reduced CLSP activity alleviates memory impairment in Alzheimer disease
Calmodulin-like skin protein (CLSP), a secreted peptide, inhibits neuronal death in cell-based Alzheimer’s disease (AD) models and transgenic overexpression of the CLSP gene suppresses synaptic loss and memory impairment in AD model mice, APPswe/PS1dE9 double transgenic mice (APP/PS1 mice). Despite...
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| Veröffentlicht in: | Transl Psychiatry |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7806720/ https://ncbi.nlm.nih.gov/pubmed/33441550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-020-01168-8 |
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