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Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation

As humans age, normal tissues, such as the esophageal epithelium, become a patchwork of mutant clones. Some mutations are under positive selection, conferring a competitive advantage over wild-type cells. We speculated that altering the selective pressure on mutant cell populations may cause them to...

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Bibliografski detalji
Izdano u:Cell Stem Cell
Glavni autori: Fernandez-Antoran, David, Piedrafita, Gabriel, Murai, Kasumi, Ong, Swee Hoe, Herms, Albert, Frezza, Christian, Jones, Philip H.
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6739485/
https://ncbi.nlm.nih.gov/pubmed/31327664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.06.011
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