Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation

Damage-associated molecular patterns (DAMPs) are molecules that can be actively or passively released by injured tissues and that activate the immune system. Here we show that nicotinate phosphoribosyltransferase (NAPRT), detected by antibody-mediated assays and mass spectrometry, is an extracellula...

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Udgivet i:Nat Commun
Main Authors: Managò, Antonella, Audrito, Valentina, Mazzola, Francesca, Sorci, Leonardo, Gaudino, Federica, Gizzi, Katiuscia, Vitale, Nicoletta, Incarnato, Danny, Minazzato, Gabriele, Ianniello, Alice, Varriale, Antonio, D’Auria, Sabato, Mengozzi, Giulio, Politano, Gianfranco, Oliviero, Salvatore, Raffaelli, Nadia, Deaglio, Silvia
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6739309/
https://ncbi.nlm.nih.gov/pubmed/31511522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12055-2
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