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Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation

Damage-associated molecular patterns (DAMPs) are molecules that can be actively or passively released by injured tissues and that activate the immune system. Here we show that nicotinate phosphoribosyltransferase (NAPRT), detected by antibody-mediated assays and mass spectrometry, is an extracellula...

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Bibliografische gegevens
Gepubliceerd in:Nat Commun
Hoofdauteurs: Managò, Antonella, Audrito, Valentina, Mazzola, Francesca, Sorci, Leonardo, Gaudino, Federica, Gizzi, Katiuscia, Vitale, Nicoletta, Incarnato, Danny, Minazzato, Gabriele, Ianniello, Alice, Varriale, Antonio, D’Auria, Sabato, Mengozzi, Giulio, Politano, Gianfranco, Oliviero, Salvatore, Raffaelli, Nadia, Deaglio, Silvia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6739309/
https://ncbi.nlm.nih.gov/pubmed/31511522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12055-2
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