Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation

Damage-associated molecular patterns (DAMPs) are molecules that can be actively or passively released by injured tissues and that activate the immune system. Here we show that nicotinate phosphoribosyltransferase (NAPRT), detected by antibody-mediated assays and mass spectrometry, is an extracellula...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Managò, Antonella, Audrito, Valentina, Mazzola, Francesca, Sorci, Leonardo, Gaudino, Federica, Gizzi, Katiuscia, Vitale, Nicoletta, Incarnato, Danny, Minazzato, Gabriele, Ianniello, Alice, Varriale, Antonio, D’Auria, Sabato, Mengozzi, Giulio, Politano, Gianfranco, Oliviero, Salvatore, Raffaelli, Nadia, Deaglio, Silvia
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6739309/
https://ncbi.nlm.nih.gov/pubmed/31511522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12055-2
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