Sustained delivery and molecular targeting of a therapeutic monoclonal antibody to metastases in the central nervous system of mice.

Approximately 15–40% of all cancers develop metastases in the central nervous system (CNS), yet few therapeutic options exist to treat them. Cancer therapies based on monoclonal antibodies are widely successful, yet have limited efficacy against CNS metastases, owing to the low levels of the drug re...

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Publicado en:Nat Biomed Eng
Main Authors: Wen, Jing, Wu, Di, Qin, Meng, Liu, Chaoyong, Wang, Lan, Xu, Duo, Vinters, Harry V., Liu, Yang, Kranz, Emiko, Guan, Xin, Sun, Guibo, Sun, Xiaobo, Lee, YooJin, Martinez-Maza, Otoniel, Widney, Daniel, Lu, Yunfeng, Chen, Irvin SY., Kamata, Masakazu
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6736720/
https://ncbi.nlm.nih.gov/pubmed/31384008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-019-0434-z
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