Sustained delivery and molecular targeting of a therapeutic monoclonal antibody to metastases in the central nervous system of mice.

Approximately 15–40% of all cancers develop metastases in the central nervous system (CNS), yet few therapeutic options exist to treat them. Cancer therapies based on monoclonal antibodies are widely successful, yet have limited efficacy against CNS metastases, owing to the low levels of the drug re...

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Gepubliceerd in:Nat Biomed Eng
Hoofdauteurs: Wen, Jing, Wu, Di, Qin, Meng, Liu, Chaoyong, Wang, Lan, Xu, Duo, Vinters, Harry V., Liu, Yang, Kranz, Emiko, Guan, Xin, Sun, Guibo, Sun, Xiaobo, Lee, YooJin, Martinez-Maza, Otoniel, Widney, Daniel, Lu, Yunfeng, Chen, Irvin SY., Kamata, Masakazu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6736720/
https://ncbi.nlm.nih.gov/pubmed/31384008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-019-0434-z
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