Enhanced Delivery of Rituximab Into Brain and Lymph Nodes Using Timed-Release Nanocapsules in Non-Human Primates

Tumor metastasis into the central nervous system (CNS) and lymph nodes (LNs) is a major obstacle for effective therapies. Therapeutic monoclonal antibodies (mAb) have revolutionized tumor treatment; however, their efficacy for treating metastatic tumors-particularly, CNS and LN metastases-is poor du...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Qin, Meng, Wang, Lan, Wu, Di, Williams, Christopher K., Xu, Duo, Kranz, Emiko, Guo, Qi, Guan, Jiaoqiong, Vinters, Harry V., Lee, YooJin, Xie, Yiming, Luo, Yun, Sun, Guibo, Sun, Xiaobo, He, Zhanlong, Lu, Yunfeng, Kamata, Masakazu, Wen, Jing, Chen, Irvin S. Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996053/
https://ncbi.nlm.nih.gov/pubmed/32047498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.03132
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