Purging Exhausted Virus-Specific CD8 T Cell Phenotypes by Somatic Cell Reprogramming

Cytotoxic T cells are critical in controlling virus infections. However, continuous antigen stimulation and negative regulatory factors cause CD8 T cells to enter a dysfunctional state (T cell exhaustion), resulting in viral persistence. We hypothesized that the exhausted T cell state could be molec...

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Detalhes bibliográficos
Publicado no:AIDS Res Hum Retroviruses
Main Authors: Chan, Joshua, Kim, Patrick Y., Kranz, Emiko, Nagaoka, Yoshiko, Lee, YooJin, Wen, Jing, Elsaesser, Heidi J., Qin, Meng, Brooks, David G., Ringpis, Gene-Errol, Chen, Irvin S.Y., Kamata, Masakazu
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5684681/
https://ncbi.nlm.nih.gov/pubmed/29140111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2017.0161
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