Ectopic expression of anti-HIV-1 shRNAs protects CD8(+) T cells modified with CD4ζ CAR from HIV-1 infection and alleviates impairment of cell proliferation

Chimeric antigen receptors (CARs) are artificially engineered receptors that confer a desired specificity to immune effector T cells. As an HIV-1-specific CAR, CD4ζ CAR has been extensively tested in vitro as well as in clinical trials. T cells modified with this CAR mediated highly potent anti-HIV-...

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Pubblicato in:Biochem Biophys Res Commun
Autori principali: Kamata, Masakazu, Kim, Patrick Y., Ng, Hwee L., Ringpis, Gene-Errol E., Kranz, Emiko, Chan, Joshua, O'Connor, Sean, Yang, Otto O., Chen, Irvin S.Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4686265/
https://ncbi.nlm.nih.gov/pubmed/25998390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2015.05.026
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