96 shRNAs designed for maximal coverage of HIV-1 variants

BACKGROUND: The RNA interference (RNAi) pathway is a mechanism of gene-suppression with potential gene therapy applications for treating viral disease such as HIV-1. The most suitable inducer of RNAi for this application is short hairpin RNA (shRNA) although it is limited to suppressing a single tar...

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Bibliografiske detaljer
Main Authors: Mcintyre, Glen John, Groneman, Jennifer Lynne, Yu, Yi-Hsin, Jaramillo, Angel, Shen, Sylvie, Applegate, Tanya Lynn
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2009
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698899/
https://ncbi.nlm.nih.gov/pubmed/19497094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-6-55
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