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An agonist of the MscL channel affects multiple bacterial species and increases membrane permeability and potency of common antibiotics

The bacterial MscL channel normally functions as an emergency release valve discharging cytoplasmic solutes upon osmotic stress. The channel opens and passes molecules up to 30 A and its pore is the largest of any gated channel. Opening the MscL pore inappropriately is detrimental to the bacterial c...

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Bibliografske podrobnosti
izdano v:Mol Microbiol
Main Authors: Wray, Robin, Herrera, Nadia, Iscla, Irene, Wang, Junmei, Blount, Paul
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6736685/
https://ncbi.nlm.nih.gov/pubmed/31177589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.14325
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