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Novel compounds that specifically bind and modulate MscL: insights into channel gating mechanisms
The bacterial mechanosensitive channel of large conductance (MscL) normally functions as an emergency release valve discharging cytoplasmic solutes upon osmotic stress. Opening the large pore of MscL inappropriately is detrimental to the cell, and thus it has been speculated to be a potential antibi...
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| Publicado no: | FASEB J |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Federation of American Societies for Experimental Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6404570/ https://ncbi.nlm.nih.gov/pubmed/30359098 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201801628R |
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