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Novel compounds that specifically bind and modulate MscL: insights into channel gating mechanisms

The bacterial mechanosensitive channel of large conductance (MscL) normally functions as an emergency release valve discharging cytoplasmic solutes upon osmotic stress. Opening the large pore of MscL inappropriately is detrimental to the cell, and thus it has been speculated to be a potential antibi...

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Bibliografiske detaljer
Udgivet i:FASEB J
Main Authors: Wray, Robin, Iscla, Irene, Kovacs, Zoltan, Wang, Junmei, Blount, Paul
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404570/
https://ncbi.nlm.nih.gov/pubmed/30359098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201801628R
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