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Defining the Physical Gate of a Mechanosensitive Channel, MscL, by Engineering Metal-Binding Sites

The mechanosensitive channel of large conductance, MscL, of Escherichia coli is one of the best-studied mechanosensitive proteins. Although the structure of the closed or “nearly-closed” state of the Mycobacterium tuberculosis ortholog has been solved and mechanisms of gating have been proposed, the...

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Main Authors: Iscla, Irene, Levin, Gal, Wray, Robin, Reynolds, Robert, Blount, Paul
פורמט: Artigo
שפה:Inglês
יצא לאור: Biophysical Society 2004
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1304787/
https://ncbi.nlm.nih.gov/pubmed/15339809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.049833
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