ULK1 phosphorylates Mad1 to regulate spindle assembly checkpoint

The spindle assembly checkpoint (SAC) ensures the fidelity of chromosome segregation during mitosis. Here, we show that ULK1, a serine/threonine kinase that plays a key role in initiation of autophagy, also has an important function in the activation of SAC. ULK1 phosphorylates the SAC protein Mad1...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Yuan, Fengjie, Jin, Ximin, Li, Dan, Song, Yuanshuai, Zhang, Nan, Yang, Xin, Wang, Lina, Zhu, Wei-Guo, Tian, Chan, Zhao, Ying
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6736072/
https://ncbi.nlm.nih.gov/pubmed/31291454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz602
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