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ULK1 phosphorylates Mad1 to regulate spindle assembly checkpoint
The spindle assembly checkpoint (SAC) ensures the fidelity of chromosome segregation during mitosis. Here, we show that ULK1, a serine/threonine kinase that plays a key role in initiation of autophagy, also has an important function in the activation of SAC. ULK1 phosphorylates the SAC protein Mad1...
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| Izdano u: | Nucleic Acids Res |
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| Glavni autori: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6736072/ https://ncbi.nlm.nih.gov/pubmed/31291454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz602 |
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