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Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint

The spindle assembly checkpoint (SAC) restrains anaphase until all chromosomes become bi-oriented on the mitotic spindle. The SAC protein Mad2 can fold into two distinct conformers, open (O) and closed (C), and can asymmetrically dimerize. Here, we describe a monoclonal antibody that specifically re...

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Bibliografiska uppgifter
Huvudupphovsmän: Fava, Luca L, Kaulich, Manuel, Nigg, Erich A, Santamaria, Anna
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2011
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160659/
https://ncbi.nlm.nih.gov/pubmed/21772247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.239
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