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Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint
The spindle assembly checkpoint (SAC) restrains anaphase until all chromosomes become bi-oriented on the mitotic spindle. The SAC protein Mad2 can fold into two distinct conformers, open (O) and closed (C), and can asymmetrically dimerize. Here, we describe a monoclonal antibody that specifically re...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2011
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3160659/ https://ncbi.nlm.nih.gov/pubmed/21772247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.239 |
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