Spindle assembly checkpoint robustness requires Tpr-mediated regulation of Mad1/Mad2 proteostasis

Tpr is a conserved nuclear pore complex (NPC) protein implicated in the spindle assembly checkpoint (SAC) by an unknown mechanism. Here, we show that Tpr is required for normal SAC response by stabilizing Mad1 and Mad2 before mitosis. Tpr coimmunoprecipitated with Mad1 and Mad2 (hereafter designated...

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Detalhes bibliográficos
Main Authors: Schweizer, Nina, Ferrás, Cristina, Kern, David M., Logarinho, Elsa, Cheeseman, Iain M., Maiato, Helder
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871433/
https://ncbi.nlm.nih.gov/pubmed/24344181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201309076
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