Caricamento...
Targeted DNA transposition in vitro using a dCas9-transposase fusion protein
Homology-directed genome engineering is limited by transgene size. Although DNA transposons are more efficient with large transgenes, random integrations are potentially mutagenic. Here we present an in vitro mechanistic study that demonstrates efficient Cas9 targeting of the mariner transposon Hsma...
Salvato in:
| Pubblicato in: | Nucleic Acids Res |
|---|---|
| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2019
|
| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6735945/ https://ncbi.nlm.nih.gov/pubmed/31429873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz552 |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !
|