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Targeted DNA transposition in vitro using a dCas9-transposase fusion protein
Homology-directed genome engineering is limited by transgene size. Although DNA transposons are more efficient with large transgenes, random integrations are potentially mutagenic. Here we present an in vitro mechanistic study that demonstrates efficient Cas9 targeting of the mariner transposon Hsma...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6735945/ https://ncbi.nlm.nih.gov/pubmed/31429873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz552 |
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