Targeted DNA methylation in human cells using engineered dCas9-methyltransferases

Mammalian genomes exhibit complex patterns of gene expression regulated, in part, by DNA methylation. The advent of engineered DNA methyltransferases (MTases) to target DNA methylation to specific sites in the genome will accelerate many areas of biological research. However, targeted MTases require...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Xiong, Tina, Meister, Glenna E., Workman, Rachael E., Kato, Nathaniel C., Spellberg, Michael J., Turker, Fulya, Timp, Winston, Ostermeier, Marc, Novina, Carl D.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5532369/
https://ncbi.nlm.nih.gov/pubmed/28751638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06757-0
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados