Genome-wide determination of on-target and off-target characteristics for RNA-guided DNA methylation by dCas9 methyltransferases

BACKGROUND: Fusion of DNA methyltransferase domains to the nuclease-deficient clustered regularly interspaced short palindromic repeat (CRISPR) associated protein 9 (dCas9) has been used for epigenome editing, but the specificities of these dCas9 methyltransferases have not been fully investigated....

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Enregistré dans:
Détails bibliographiques
Publié dans:Gigascience
Auteurs principaux: Lin, Lin, Liu, Yong, Xu, Fengping, Huang, Jinrong, Daugaard, Tina Fuglsang, Petersen, Trine Skov, Hansen, Bettina, Ye, Lingfei, Zhou, Qing, Fang, Fang, Yang, Ling, Li, Shengting, Fløe, Lasse, Jensen, Kristopher Torp, Shrock, Ellen, Chen, Fang, Yang, Huanming, Wang, Jian, Liu, Xin, Xu, Xun, Bolund, Lars, Nielsen, Anders Lade, Luo, Yonglun
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2018
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5888497/
https://ncbi.nlm.nih.gov/pubmed/29635374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gigascience/giy011
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