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Genome-wide determination of on-target and off-target characteristics for RNA-guided DNA methylation by dCas9 methyltransferases
BACKGROUND: Fusion of DNA methyltransferase domains to the nuclease-deficient clustered regularly interspaced short palindromic repeat (CRISPR) associated protein 9 (dCas9) has been used for epigenome editing, but the specificities of these dCas9 methyltransferases have not been fully investigated....
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| Publié dans: | Gigascience |
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| Auteurs principaux: | , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5888497/ https://ncbi.nlm.nih.gov/pubmed/29635374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gigascience/giy011 |
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