Genome-wide determination of on-target and off-target characteristics for RNA-guided DNA methylation by dCas9 methyltransferases

BACKGROUND: Fusion of DNA methyltransferase domains to the nuclease-deficient clustered regularly interspaced short palindromic repeat (CRISPR) associated protein 9 (dCas9) has been used for epigenome editing, but the specificities of these dCas9 methyltransferases have not been fully investigated....

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Gigascience
المؤلفون الرئيسيون: Lin, Lin, Liu, Yong, Xu, Fengping, Huang, Jinrong, Daugaard, Tina Fuglsang, Petersen, Trine Skov, Hansen, Bettina, Ye, Lingfei, Zhou, Qing, Fang, Fang, Yang, Ling, Li, Shengting, Fløe, Lasse, Jensen, Kristopher Torp, Shrock, Ellen, Chen, Fang, Yang, Huanming, Wang, Jian, Liu, Xin, Xu, Xun, Bolund, Lars, Nielsen, Anders Lade, Luo, Yonglun
التنسيق: Artigo
اللغة:Inglês
منشور في: Oxford University Press 2018
الموضوعات:
Research
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC5888497/
https://ncbi.nlm.nih.gov/pubmed/29635374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gigascience/giy011
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