Genome-wide determination of on-target and off-target characteristics for RNA-guided DNA methylation by dCas9 methyltransferases

BACKGROUND: Fusion of DNA methyltransferase domains to the nuclease-deficient clustered regularly interspaced short palindromic repeat (CRISPR) associated protein 9 (dCas9) has been used for epigenome editing, but the specificities of these dCas9 methyltransferases have not been fully investigated....

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Gigascience
Päätekijät: Lin, Lin, Liu, Yong, Xu, Fengping, Huang, Jinrong, Daugaard, Tina Fuglsang, Petersen, Trine Skov, Hansen, Bettina, Ye, Lingfei, Zhou, Qing, Fang, Fang, Yang, Ling, Li, Shengting, Fløe, Lasse, Jensen, Kristopher Torp, Shrock, Ellen, Chen, Fang, Yang, Huanming, Wang, Jian, Liu, Xin, Xu, Xun, Bolund, Lars, Nielsen, Anders Lade, Luo, Yonglun
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2018
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5888497/
https://ncbi.nlm.nih.gov/pubmed/29635374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gigascience/giy011
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia