DNA targeting by Clostridium cellulolyticum CRISPR–Cas9 Type II-C system

Type II CRISPR–Cas9 RNA-guided nucleases are widely used for genome engineering. Type II-A SpCas9 protein from Streptococcus pyogenes is the most investigated and highly used enzyme of its class. Nevertheless, it has some drawbacks, including a relatively big size, imperfect specificity and restrict...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Fedorova, Iana, Arseniev, Anatolii, Selkova, Polina, Pobegalov, Georgii, Goryanin, Ignatiy, Vasileva, Aleksandra, Musharova, Olga, Abramova, Marina, Kazalov, Maksim, Zyubko, Tatyana, Artamonova, Tatyana, Artamonova, Daria, Shmakov, Sergey, Khodorkovskii, Mikhail, Severinov, Konstantin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Nucleic Acid Enzymes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038990/
https://ncbi.nlm.nih.gov/pubmed/31943070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1225
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