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Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein
Comprehensive studies have shown that DNA methylation plays vital roles in both loss of pluripotency and governance of the transcriptome during embryogenesis and subsequent developmental processes. Aberrant DNA methylation patterns have been widely observed in tumorigenesis, ageing and neurodegenera...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5508226/ https://ncbi.nlm.nih.gov/pubmed/28695892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms16026 |
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