DNA epigenome editing using CRISPR-Cas SunTag-directed DNMT3A

BACKGROUND: DNA methylation has widespread effects on gene expression during development. However, our ability to assign specific function to regions of DNA methylation is limited by the poor correlation between global patterns of DNA methylation and gene expression. RESULTS: Here, we utilize nuclea...

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Vydáno v:Genome Biol
Hlavní autoři: Huang, Yung-Hsin, Su, Jianzhong, Lei, Yong, Brunetti, Lorenzo, Gundry, Michael C., Zhang, Xiaotian, Jeong, Mira, Li, Wei, Goodell, Margaret A.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5604343/
https://ncbi.nlm.nih.gov/pubmed/28923089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1306-z
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