A modular dCas9-SunTag DNMT3A epigenome editing system overcomes pervasive off-target activity of direct fusion dCas9-DNMT3A constructs

Detection of DNA methylation in the genome has been possible for decades; however, the ability to deliberately and specifically manipulate local DNA methylation states in the genome has been extremely limited. Consequently, this has impeded our understanding of the direct effect of DNA methylation o...

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Bibliografische gegevens
Gepubliceerd in:Genome Res
Hoofdauteurs: Pflueger, Christian, Tan, Dennis, Swain, Tessa, Nguyen, Trung, Pflueger, Jahnvi, Nefzger, Christian, Polo, Jose M., Ford, Ethan, Lister, Ryan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071642/
https://ncbi.nlm.nih.gov/pubmed/29907613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.233049.117
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