A central core disease mutation in the Ca(2+)-binding site of skeletal muscle ryanodine receptor impairs single-channel regulation

Cryoelectron microscopy and mutational analyses have shown that type 1 ryanodine receptor (RyR1) amino acid residues RyR1-E3893, -E3967, and -T5001 are critical for Ca(2+)-mediated activation of skeletal muscle Ca(2+) release channel. De novo missense mutation RyR1-Q3970K in the secondary binding sp...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Am J Physiol Cell Physiol
Autores principales: Chirasani, Venkat R., Xu, Le, Addis, Hannah G., Pasek, Daniel A., Dokholyan, Nikolay V., Meissner, Gerhard, Yamaguchi, Naohiro
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2019
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6732417/
https://ncbi.nlm.nih.gov/pubmed/31166712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00052.2019
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares