Glioblastoma Recurrence and the Role of O(6)-Methylguanine–DNA Methyltransferase Promoter Methylation

Tumor recurrence in glioblastoma multiforme (GBM) is often attributed to acquired resistance to the standard chemotherapeutic agent, temozolomide (TMZ). Promoter methylation of the DNA repair gene MGMT (O(6)-methylguanine–DNA methyltransferase) has been associated with sensitivity to TMZ, whereas in...

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Detalhes bibliográficos
Publicado no:JCO Clin Cancer Inform
Main Authors: Storey, Katie, Leder, Kevin, Hawkins-Daarud, Andrea, Swanson, Kristin, Ahmed, Atique U., Rockne, Russell C., Foo, Jasmine
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2019
Assuntos:
ORIGINAL REPORT
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6732255/
https://ncbi.nlm.nih.gov/pubmed/30758983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/CCI.18.00062
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