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Glioblastoma Recurrence and the Role of O(6)-Methylguanine–DNA Methyltransferase Promoter Methylation
Tumor recurrence in glioblastoma multiforme (GBM) is often attributed to acquired resistance to the standard chemotherapeutic agent, temozolomide (TMZ). Promoter methylation of the DNA repair gene MGMT (O(6)-methylguanine–DNA methyltransferase) has been associated with sensitivity to TMZ, whereas in...
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| 出版年: | JCO Clin Cancer Inform |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Clinical Oncology
2019
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6732255/ https://ncbi.nlm.nih.gov/pubmed/30758983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/CCI.18.00062 |
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