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Glioblastoma Recurrence and the Role of O(6)-Methylguanine–DNA Methyltransferase Promoter Methylation

Tumor recurrence in glioblastoma multiforme (GBM) is often attributed to acquired resistance to the standard chemotherapeutic agent, temozolomide (TMZ). Promoter methylation of the DNA repair gene MGMT (O(6)-methylguanine–DNA methyltransferase) has been associated with sensitivity to TMZ, whereas in...

詳細記述

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書誌詳細
出版年:JCO Clin Cancer Inform
主要な著者: Storey, Katie, Leder, Kevin, Hawkins-Daarud, Andrea, Swanson, Kristin, Ahmed, Atique U., Rockne, Russell C., Foo, Jasmine
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Clinical Oncology 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6732255/
https://ncbi.nlm.nih.gov/pubmed/30758983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/CCI.18.00062
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