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Second messenger cA(4) formation within the composite Csm1 Palm pocket of type III-A CRISPR-Cas Csm complex and its release path

Target RNA binding to crRNA-bound type III-A CRISPR-Cas multi-subunit Csm surveillance complexes activates cyclic-oligoadenylate (cA(n)) formation from ATP subunits positioned within the composite pair of Palm domain pockets of the Csm1 subunit. The generated cA(n) second messenger in turn targets t...

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Publicado en:Mol Cell
Main Authors: Jia, Ning, Jones, Roger, Sukenick, George, Patel, Dinshaw J.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731140/
https://ncbi.nlm.nih.gov/pubmed/31326272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.06.013
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