RNA Targeting by the Type III-A CRISPR-Cas Csm Complex of Thermus thermophilus

CRISPR-Cas is a prokaryotic adaptive immune system that provides sequence-specific defense against foreign nucleic acids. Here we report the structure and function of the effector complex of the Type III-A CRISPR-Cas system of Thermus thermophilus: the Csm complex (TtCsm). TtCsm is composed of five...

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Pubblicato in:Mol Cell
Autori principali: Staals, Raymond H. J., Zhu, Yifan, Taylor, David W., Kornfeld, Jack E., Sharma, Kundan, Barendregt, Arjan, Koehorst, Jasper J., Vlot, Marnix, Neupane, Nirajan, Varossieau, Koen, Sakamoto, Keiko, Suzuki, Takehiro, Dohmae, Naoshi, Yokoyama, Shigeyuki, Schaap, Peter J., Urlaub, Henning, Heck, Albert J. R., Nogales, Eva, Doudna, Jennifer A., Shinkai, Akeo, van der Oost, John
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342149/
https://ncbi.nlm.nih.gov/pubmed/25457165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.10.005
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