RNA Targeting by the Type III-A CRISPR-Cas Csm Complex of Thermus thermophilus

CRISPR-Cas is a prokaryotic adaptive immune system that provides sequence-specific defense against foreign nucleic acids. Here we report the structure and function of the effector complex of the Type III-A CRISPR-Cas system of Thermus thermophilus: the Csm complex (TtCsm). TtCsm is composed of five...

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Publicado no:Mol Cell
Main Authors: Staals, Raymond H. J., Zhu, Yifan, Taylor, David W., Kornfeld, Jack E., Sharma, Kundan, Barendregt, Arjan, Koehorst, Jasper J., Vlot, Marnix, Neupane, Nirajan, Varossieau, Koen, Sakamoto, Keiko, Suzuki, Takehiro, Dohmae, Naoshi, Yokoyama, Shigeyuki, Schaap, Peter J., Urlaub, Henning, Heck, Albert J. R., Nogales, Eva, Doudna, Jennifer A., Shinkai, Akeo, van der Oost, John
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342149/
https://ncbi.nlm.nih.gov/pubmed/25457165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.10.005
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