Structure and activity of the RNA-targeting Type III-B CRISPR-Cas complex of Thermus thermophilus

The CRISPR-Cas system is a prokaryotic host defense system against genetic elements. The Type III-B CRISPR-Cas system of the bacterium Thermus thermophilus, the TtCmr complex, is composed of six different protein subunits (Cmr1-6) and one crRNA with a stoichiometry of Cmr1(1)2(1)3(1)4(4)5(3)6(1):crR...

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Main Authors: Staals, Raymond H.J., Agari, Yoshihiro, Maki-Yonekura, Saori, Zhu, Yifan, Taylor, David W., van Duijn, Esther, Barendregt, Arjan, Vlot, Marnix, Koehorst, Jasper J., Sakamoto, Keiko, Masuda, Akiko, Dohmae, Naoshi, Schaap, Peter J., Doudna, Jennifer A., Heck, Albert J.R., Yonekura, Koji, van der Oost, John, Shinkai, Akeo
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006948/
https://ncbi.nlm.nih.gov/pubmed/24119403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.09.013
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