Structure and activity of the RNA-targeting Type III-B CRISPR-Cas complex of Thermus thermophilus

The CRISPR-Cas system is a prokaryotic host defense system against genetic elements. The Type III-B CRISPR-Cas system of the bacterium Thermus thermophilus, the TtCmr complex, is composed of six different protein subunits (Cmr1-6) and one crRNA with a stoichiometry of Cmr1(1)2(1)3(1)4(4)5(3)6(1):crR...

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Hauptverfasser: Staals, Raymond H.J., Agari, Yoshihiro, Maki-Yonekura, Saori, Zhu, Yifan, Taylor, David W., van Duijn, Esther, Barendregt, Arjan, Vlot, Marnix, Koehorst, Jasper J., Sakamoto, Keiko, Masuda, Akiko, Dohmae, Naoshi, Schaap, Peter J., Doudna, Jennifer A., Heck, Albert J.R., Yonekura, Koji, van der Oost, John, Shinkai, Akeo
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006948/
https://ncbi.nlm.nih.gov/pubmed/24119403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.09.013
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