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Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation and Autoimmunity
Type III CRISPR-Cas systems provide robust immunity against foreign RNA/DNA by sequence-specific RNase and target RNA-activated sequence-nonspecific DNase/RNase activities. We report on cryo-EM structures of Thermococcus onnurineus Csm(crRNA) binary, Csm(crRNA)-target RNA and Csm(crRNA)-target RNA(a...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6355164/ https://ncbi.nlm.nih.gov/pubmed/30503773 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.11.007 |
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