Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation and Autoimmunity

Type III CRISPR-Cas systems provide robust immunity against foreign RNA/DNA by sequence-specific RNase and target RNA-activated sequence-nonspecific DNase/RNase activities. We report on cryo-EM structures of Thermococcus onnurineus Csm(crRNA) binary, Csm(crRNA)-target RNA and Csm(crRNA)-target RNA(a...

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Bibliografiska uppgifter
I publikationen:Mol Cell
Huvudupphovsmän: Jia, Ning, Mo, Charlie Y., Wang, Chongyuan, Eng, Edward T., Marraffini, Luciano A., Patel, Dinshaw J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355164/
https://ncbi.nlm.nih.gov/pubmed/30503773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.11.007
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