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CRISPR DNA base editors with reduced RNA off-target and self-editing activities
Cytosine or adenine base editors (CBEs or ABEs) can introduce specific DNA C-to-T or A-to-G alterations(1–4). However, we recently demonstrated that they can also induce widespread guide RNA-independent RNA base edits(5) and created SElective Curbing of Unwanted RNA Editing (SECURE)-BE3 variants tha...
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| Publicado no: | Nat Biotechnol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6730565/ https://ncbi.nlm.nih.gov/pubmed/31477922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-019-0236-6 |
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