Intracerebral Transplantation of Adult Mouse Neural Progenitor Cells into the Niemann-Pick-A Mouse Leads to a Marked Decrease in Lysosomal Storage Pathology

Niemann-Pick disease is caused by a genetic deficiency in acid sphingomyelinase (ASM) leading to the intracellular accumulation of sphingomyelin and cholesterol in lysosomes. In the present study, we evaluated the effects of direct intracerebral transplantation of neural progenitor cells (NPCs) on t...

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Détails bibliographiques
Publié dans:J Neurosci
Auteurs principaux: Shihabuddin, L. S., Numan, S., Huff, M. R., Dodge, J. C., Clarke, J., Macauley, S. L., Yang, W., Taksir, T. V., Parsons, G., Passini, M. A., Gage, F. H., Stewart, G. R.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2004
Sujets:
Neurobiology of Disease
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6730128/
https://ncbi.nlm.nih.gov/pubmed/15564580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3584-04.2004
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