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β-Amyloid Peptides Induce Mitochondrial Dysfunction and Oxidative Stress in Astrocytes and Death of Neurons through Activation of NADPH Oxidase

β-Amyloid (βA) peptide is strongly implicated in the neurodegeneration underlying Alzheimer's disease, but the mechanisms of neurotoxicity remain controversial. This study establishes a central role for oxidative stress by the activation of NADPH oxidase in astrocytes as the cause of βA-induced...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Neurosci
Prif Awduron: Abramov, Andrey Y., Canevari, Laura, Duchen, Michael R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2004
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729998/
https://ncbi.nlm.nih.gov/pubmed/14724257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4042-03.2004
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