Locking the Dimeric GABA(B) G-Protein-Coupled Receptor in Its Active State

G-protein-coupled receptors (GPCRs) play a major role in cell-cell communication in the CNS. These proteins oscillate between various inactive and active conformations, the latter being stabilized by agonists. Although mutations can lead to constitutive activity, most of these destabilize inactive c...

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Bibliographische Detailangaben
Veröffentlicht in:J Neurosci
Hauptverfasser: Kniazeff, Julie, Saintot, Pierre-Philippe, Goudet, Cyril, Liu, Jianfeng, Charnet, Annie, Guillon, Gilles, Pin, Jean-Philippe
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2004
Schlagworte:
Cellular/Molecular
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729975/
https://ncbi.nlm.nih.gov/pubmed/14724235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3141-03.2004
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