Locking the Dimeric GABA(B) G-Protein-Coupled Receptor in Its Active State

G-protein-coupled receptors (GPCRs) play a major role in cell-cell communication in the CNS. These proteins oscillate between various inactive and active conformations, the latter being stabilized by agonists. Although mutations can lead to constitutive activity, most of these destabilize inactive c...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Neurosci
Auteurs principaux: Kniazeff, Julie, Saintot, Pierre-Philippe, Goudet, Cyril, Liu, Jianfeng, Charnet, Annie, Guillon, Gilles, Pin, Jean-Philippe
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2004
Sujets:
Cellular/Molecular
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729975/
https://ncbi.nlm.nih.gov/pubmed/14724235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3141-03.2004
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