Locking the Dimeric GABA(B) G-Protein-Coupled Receptor in Its Active State

G-protein-coupled receptors (GPCRs) play a major role in cell-cell communication in the CNS. These proteins oscillate between various inactive and active conformations, the latter being stabilized by agonists. Although mutations can lead to constitutive activity, most of these destabilize inactive c...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Kniazeff, Julie, Saintot, Pierre-Philippe, Goudet, Cyril, Liu, Jianfeng, Charnet, Annie, Guillon, Gilles, Pin, Jean-Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2004
Assuntos:
Cellular/Molecular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729975/
https://ncbi.nlm.nih.gov/pubmed/14724235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3141-03.2004
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