Dual Roles of the C(2)B Domain of Synaptotagmin I in Synchronizing Ca(2+)-Dependent Neurotransmitter Release

Although the vesicular protein synaptotagmin I contains two Ca(2+)-binding domains (C(2)A and C(2)B), Ca(2+) binding to the C(2)B domain is more important for triggering synchronous neurotransmitter release. We have used point mutagenesis to determine the functional contributions of the five negativ...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Nishiki, Tei-ichi, Augustine, George J.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2004
Subjects:
Cellular/Molecular
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729890/
https://ncbi.nlm.nih.gov/pubmed/15456828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2545-04.2004
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