Highly Selective and Prolonged Depletion of Mitochondrial Glutathione in Astrocytes Markedly Increases Sensitivity to Peroxynitrite

Glutathione, a major endogenous antioxidant, is found in two intracellular pools in the cytoplasm and the mitochondria. To investigate the importance of the smaller mitochondrial pool, we developed conditions based on treatment with ethacrynic acid that produced near-complete and highly selective de...

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Bibliografiska uppgifter
I publikationen:J Neurosci
Huvudupphovsmän: Muyderman, Håkan, Nilsson, Michael, Sims, Neil R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Society for Neuroscience 2004
Ämnen:
Neurobiology of Disease
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729783/
https://ncbi.nlm.nih.gov/pubmed/15371502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1103-04.2004
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