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Highly Selective and Prolonged Depletion of Mitochondrial Glutathione in Astrocytes Markedly Increases Sensitivity to Peroxynitrite

Glutathione, a major endogenous antioxidant, is found in two intracellular pools in the cytoplasm and the mitochondria. To investigate the importance of the smaller mitochondrial pool, we developed conditions based on treatment with ethacrynic acid that produced near-complete and highly selective de...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Neurosci
Prif Awduron: Muyderman, Håkan, Nilsson, Michael, Sims, Neil R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2004
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729783/
https://ncbi.nlm.nih.gov/pubmed/15371502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1103-04.2004
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