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Highly Selective and Prolonged Depletion of Mitochondrial Glutathione in Astrocytes Markedly Increases Sensitivity to Peroxynitrite

Glutathione, a major endogenous antioxidant, is found in two intracellular pools in the cytoplasm and the mitochondria. To investigate the importance of the smaller mitochondrial pool, we developed conditions based on treatment with ethacrynic acid that produced near-complete and highly selective de...

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Détails bibliographiques
Publié dans:J Neurosci
Auteurs principaux: Muyderman, Håkan, Nilsson, Michael, Sims, Neil R.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2004
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729783/
https://ncbi.nlm.nih.gov/pubmed/15371502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1103-04.2004
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