Glutathione export by human lymphoid cells: depletion of glutathione by inhibition of its synthesis decreases export and increases sensitivity to irradiation.

Glutathione (in the form of GSH) is transported out of cultured human lymphoid cells at rates proportional to the intracellular glutathione levels. Inhibition of glutathione synthesis by buthionine sulfoximine, a potent selective inhibitor of gamma-glutamylcysteine synthetase, leads to exponential d...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Dethmers, J K, Meister, A
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1981
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC349294/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6950392/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.12.7492
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