Dimeric Amyloid β Protein Rapidly Accumulates in Lipid Rafts followed by Apolipoprotein E and Phosphorylated Tau Accumulation in the Tg2576 Mouse Model of Alzheimer's Disease

To investigate lipid rafts as a site where amyloid β protein (Aβ) oligomers might accumulate and cause toxicity in Alzheimer's disease (AD), we analyzed Aβ in the Tg2576 transgenic mouse model of AD. Aβ was highly concentrated in lipid rafts, which comprise a small fraction of brain volume but...

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Opis bibliograficzny
Wydane w:J Neurosci
Główni autorzy: Kawarabayashi, Takeshi, Shoji, Mikio, Younkin, Linda H., Wen-Lang, Lin, Dickson, Dennis W., Murakami, Tetsuro, Matsubara, Etsuro, Abe, Koji, Ashe, Karen Hsiao, Younkin, Steven G.
Format: Artigo
Język:Inglês
Wydane: Society for Neuroscience 2004
Hasła przedmiotowe:
Neurobiology of Disease
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729359/
https://ncbi.nlm.nih.gov/pubmed/15084661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5543-03.2004
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