Dimeric Amyloid β Protein Rapidly Accumulates in Lipid Rafts followed by Apolipoprotein E and Phosphorylated Tau Accumulation in the Tg2576 Mouse Model of Alzheimer's Disease

To investigate lipid rafts as a site where amyloid β protein (Aβ) oligomers might accumulate and cause toxicity in Alzheimer's disease (AD), we analyzed Aβ in the Tg2576 transgenic mouse model of AD. Aβ was highly concentrated in lipid rafts, which comprise a small fraction of brain volume but...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Kawarabayashi, Takeshi, Shoji, Mikio, Younkin, Linda H., Wen-Lang, Lin, Dickson, Dennis W., Murakami, Tetsuro, Matsubara, Etsuro, Abe, Koji, Ashe, Karen Hsiao, Younkin, Steven G.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2004
Subjects:
Neurobiology of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729359/
https://ncbi.nlm.nih.gov/pubmed/15084661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5543-03.2004
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