Cortical Neuronal and Glial Pathology in TgTau(P301L) Transgenic Mice : Neuronal Degeneration, Memory Disturbance, and Phenotypic Variation

Recapitulation of tau pathologies in an animal model has been a long-standing goal in neurodegenerative disease research. We generated transgenic (TgTau(P301L)) mice expressing a frontotemporal dementia with parkinsonism linked to chromosome 17 (FTPD-17) mutation within the longest form of tau (2N,...

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Detalhes bibliográficos
Main Authors: Murakami, Tetsuro, Paitel, Erwan, Kawarabayashi, Takeshi, Ikeda, Masaki, Chishti, M. Azhar, Janus, Christopher, Matsubara, Etsuro, Sasaki, Atsushi, Kawarai, Toshitaka, Phinney, Amie L., Harigaya, Yasuo, Horne, Patrick, Egashira, Nobuaki, Mishima, Kenichi, Hanna, Amanda, Yang, Jing, Iwasaki, Katsunori, Takahashi, Mitsuo, Fujiwara, Michihiro, Ishiguro, Koichi, Bergeron, Catherine, Carlson, George A., Abe, Koji, Westaway, David, St. George-Hyslop, Peter, Shoji, Mikio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2006
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698843/
https://ncbi.nlm.nih.gov/pubmed/17003492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.051250
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