Catabolism of endogenous and overexpressed APH1a and PEN2: evidence for artifactual involvement of the proteasome in the degradation of overexpressed proteins

PS (presenilin)-dependent γ-secretase occurs as a high-molecular-mass complex composed of either PS1 or PS2 associated with Nct (nicastrin), PEN2 (presenilin enhancer 2 homologue) and APH1 (anterior pharynx defective 1 homologue). Numerous reports have documented the very complicated physical and fu...

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Hlavní autoři: Dunys, Julie, Kawarai, Toshitaka, Wilk, Sherwin, St. George-Hyslop, Peter, Alves Da Costa, Cristine, Checler, Frédéric
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2006
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1408681/
https://ncbi.nlm.nih.gov/pubmed/16302845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051197
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