Cortical Neuronal and Glial Pathology in TgTau(P301L) Transgenic Mice : Neuronal Degeneration, Memory Disturbance, and Phenotypic Variation

Recapitulation of tau pathologies in an animal model has been a long-standing goal in neurodegenerative disease research. We generated transgenic (TgTau(P301L)) mice expressing a frontotemporal dementia with parkinsonism linked to chromosome 17 (FTPD-17) mutation within the longest form of tau (2N,...

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Main Authors: Murakami, Tetsuro, Paitel, Erwan, Kawarabayashi, Takeshi, Ikeda, Masaki, Chishti, M. Azhar, Janus, Christopher, Matsubara, Etsuro, Sasaki, Atsushi, Kawarai, Toshitaka, Phinney, Amie L., Harigaya, Yasuo, Horne, Patrick, Egashira, Nobuaki, Mishima, Kenichi, Hanna, Amanda, Yang, Jing, Iwasaki, Katsunori, Takahashi, Mitsuo, Fujiwara, Michihiro, Ishiguro, Koichi, Bergeron, Catherine, Carlson, George A., Abe, Koji, Westaway, David, St. George-Hyslop, Peter, Shoji, Mikio
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2006
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Regular Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698843/
https://ncbi.nlm.nih.gov/pubmed/17003492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.051250
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