Rescue of Mesencephalic Dopaminergic Neurons in Culture by Low-Level Stimulation of Voltage-Gated Sodium Channels

We used a model system in which dopaminergic (DA) neurons from embryonic rat mesencephalon undergo spontaneous and selective degeneration as they develop in culture. Here, we show that DA cell loss can be prevented efficiently by low concentrations of the Na(+) channel agonist veratridine. The survi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Neurosci
Hauptverfasser: Salthun-Lassalle, Bénédicte, Hirsch, Etienne C., Wolfart, Jakob, Ruberg, Merle, Michel, Patrick P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2004
Schlagworte:
Development/Plasticity/Repair
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729237/
https://ncbi.nlm.nih.gov/pubmed/15229240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5668-03.2004
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