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Excitability Constraints on Voltage-Gated Sodium Channels

We study how functional constraints bound and shape evolution through an analysis of mammalian voltage-gated sodium channels. The primary function of sodium channels is to allow the propagation of action potentials. Since Hodgkin and Huxley, mathematical models have suggested that sodium channel pro...

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Autors principals: Angelino, Elaine, Brenner, Michael P
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1988852/
https://ncbi.nlm.nih.gov/pubmed/17892320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.0030177
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